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KMID : 0369820090390010019
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Jorunal of Korean Pharmaceutical Sciences
2009 Volume.39 No. 1 p.19 ~ p.22
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Enhanced Transdermal Delivery of Furosemide from the EVA Matrix through the Rat Skin
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Chang Ik-Hyeon
Shin Sang-Chul
Cho Hwa-Young
Noh Jin-Hyung
Park Jung-Chan
Park Yong-Sun
Kim Seong-Jin
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Abstract
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This study was performed to examine the possibility of increasing the level of furosemide permeation from the ethylene-vinyl acetate (EVA) matrix through the skin by incorporating various enhancers in the EVA matrix. The effects of the enhancers on the level of furosemide permeation through the skin were evaluated using Franz diffusion cells with intact excised rat skins. The enhancers examined were the fatty acids (saturated, unsaturated), the pyrrolidones, the propylene glycol derivatives, the glycerides and the non-ionic surfactants. Among the enhancers used, polyoxyethylene-2-oleyl ether (a non-ionic surfactant) showed the best enhancement. The polyoxyethylene 2-oleyl ether as a permeation enhancer could be used for development of furosemide-EVA transdermal matrix system.
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KEYWORD
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Furosemide, Ethylene-vinyl acctate, Transdermal delivery, Penetration enhancer, Matrix, Skin permeation
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